different realities

I'm always seeing on tv shows some ways to pick up girls. The shows I'm referring to are Friends, Seinfeld, Two and a Half Men, and other comedy shows. Some of the characters pick up women, and I've always wondered if it would work in reality. The writers of the shows have to have some basis for writing the pick-up lines the characters use in the show. If I were to go up to a girl, and use one of the lines the character uses with the same tone, diction, hand gesture, and facial features, would it work? I am very tempted to experiment on this. Joey from Friends can walk by a girl, give her a smile and say "How You Doin'?" The woman would stop and start talking to Joey. If I were to smile, wink, and say "How ya Doing?" to a random girl I walk by, would it work? Probably not, but is there any true consequence of trying? No, which tempts me to really try it. Jerry from Seinfeld in one episode, I thinks picks up a woman in a grocery store. He makes some crack at the item she is looking at or holding, and she obviously laughs, and they start talking. Can I walk up to a girl at Fresh Grocer or 7-11, and make a lil' joke about something she is holding or looking, and strike up a conversation right then and there? Maybe, because that is more plausible. Just smiling, winking, and asking a girl how's she doing as a degree of creepiness and weirdness attached to it. However, talking to a girl about something that your both looking at holds more possibilities of a future conversation.